Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes

A tungsten-catalyzed hydroboration of unactivated alkenes at distal C­(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 143; no. 37; pp. 14981 - 14986
Main Authors Jankins, Tanner C, Martin-Montero, Raul, Cooper, Phillippa, Martin, Ruben, Engle, Keary M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 22.09.2021
Amer Chemical Soc
Subjects
Alkenes - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Tungsten - chemistry
FUNCTIONALIZATION
BORON
TANDEM
COMPLEXES
REACTIVITY
REMOTE
GE
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Summary:A tungsten-catalyzed hydroboration of unactivated alkenes at distal C­(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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T. C. Jankins and R. Martin-Montero contributed equally to this work.
ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.1c07162