A Fluorescent Sensor with High Selectivity and Sensitivity for Potassium in Water

• Published in: Journal of the American Chemical Society Vol. 125; no. 6; pp. 1468 - 1469
• Main Authors: He, Huarui, Mortellaro, Mark A., Leiner, Marc J. P., Fraatz, Robert J., Tusa, James K.
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 12.02.2003; Amer Chemical Soc
• Subjects: 1-Naphthylamine - analogs & derivatives; 1-Naphthylamine - chemistry; Analytical chemistry; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Biosensing Techniques - methods; Chemistry; Chemistry, Multidisciplinary; Ethers, Cyclic - chemistry; Exact sciences and technology; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fundamental and applied biological sciences. Psychology; General, instrumentation; Hydrogen-Ion Concentration; Inorganic compounds; Ionophores - chemical synthesis; Ionophores - chemistry; Kinetics; Naphthalimides; Other biological molecules; Physical Sciences; Potassium - analysis; Potassium - blood; Quinolones - chemistry; Science & Technology; Sensitivity and Specificity; Solutions; Spectrometry, Fluorescence - methods; Water - chemistry; Performance evaluation; Extracellular fluid; Fluorescence detector; Ionic selectivity; Alkali metal Complexes; Chemical sensor; Potassium Complexes
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja0284761

This communication describes a new optical sensor suitable for practical measurement of extracellular (serum or whole blood) potassium. The sensor responds rapidly and reversibly to changes in potassium concentrations typical of whole blood samples. No interferences from clinical concentrations of calcium or pH are observed, and the sodium interference is very minor. Excitation and emission occur in the visible light region. This new potassium sensor is currently used in the Roche OPTI CCA, a commercially available whole blood analyzer.