Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions

• Published in: Journal of the American Chemical Society Vol. 136; no. 20; pp. 7492 - 7497
• Main Authors: Liu, Guhuan, Wang, Xiaorui, Hu, Jinming, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.05.2014
• Subjects: Alkaline Phosphatase - antagonists & inhibitors; Alkaline Phosphatase - chemistry; Alkaline Phosphatase - metabolism; composite polymers; depolymerization; drugs; encapsulation; enzymatic reactions; Hydrogen-Ion Concentration; hydrophilicity; Hydrophobic and Hydrophilic Interactions; hydrophobicity; Light; Lipase - antagonists & inhibitors; Lipase - chemistry; Lipase - metabolism; Molecular Structure; oxygen; Particle Size; Polymerization; Polymers - chemistry; Polymers - metabolism; protons; Surface Properties; ultraviolet radiation

Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks...