Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions
Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks...
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| Published in | Journal of the American Chemical Society Vol. 136; no. 20; pp. 7492 - 7497 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
21.05.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic block copolymers bearing this motif self-assemble into self-immolative polymersomes (SIPsomes). By modular design of terminal capping moieties, visible light, UV light, and reductive milieu can be utilized to actuate SIPsomes disintegration into water-soluble small molecules and hydrophilic blocks. The design of SIPsomes allows for triggered drug co-release and controllable access toward protons, oxygen, and enzymatic substrates. We also demonstrate programmed (OR-, AND-, and XOR-type logic) enzymatic reactions by integrating SIPsome encapsulation and trigger/capping moiety-selective cascade depolymerization events. |
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| AbstractList | Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic block copolymers bearing this motif self-assemble into self-immolative polymersomes (SIPsomes). By modular design of terminal capping moieties, visible light, UV light, and reductive milieu can be utilized to actuate SIPsomes disintegration into water-soluble small molecules and hydrophilic blocks. The design of SIPsomes allows for triggered drug co-release and controllable access toward protons, oxygen, and enzymatic substrates. We also demonstrate programmed (OR-, AND-, and XOR-type logic) enzymatic reactions by integrating SIPsome encapsulation and trigger/capping moiety-selective cascade depolymerization events. Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic block copolymers bearing this motif self-assemble into self-immolative polymersomes (SIPsomes). By modular design of terminal capping moieties, visible light, UV light, and reductive milieu can be utilized to actuate SIPsomes disintegration into water-soluble small molecules and hydrophilic blocks. The design of SIPsomes allows for triggered drug co-release and controllable access toward protons, oxygen, and enzymatic substrates. We also demonstrate programmed (OR-, AND-, and XOR-type logic) enzymatic reactions by integrating SIPsome encapsulation and trigger/capping moiety-selective cascade depolymerization events.Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic block copolymers bearing this motif self-assemble into self-immolative polymersomes (SIPsomes). By modular design of terminal capping moieties, visible light, UV light, and reductive milieu can be utilized to actuate SIPsomes disintegration into water-soluble small molecules and hydrophilic blocks. The design of SIPsomes allows for triggered drug co-release and controllable access toward protons, oxygen, and enzymatic substrates. We also demonstrate programmed (OR-, AND-, and XOR-type logic) enzymatic reactions by integrating SIPsome encapsulation and trigger/capping moiety-selective cascade depolymerization events. |
| Author | Zhang, Guoying Liu, Guhuan Hu, Jinming Wang, Xiaorui Liu, Shiyong |
| AuthorAffiliation | University of Science and Technology of China CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering |
| AuthorAffiliation_xml | – name: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering – name: University of Science and Technology of China |
| Author_xml | – sequence: 1 givenname: Guhuan surname: Liu fullname: Liu, Guhuan – sequence: 2 givenname: Xiaorui surname: Wang fullname: Wang, Xiaorui – sequence: 3 givenname: Jinming surname: Hu fullname: Hu, Jinming – sequence: 4 givenname: Guoying surname: Zhang fullname: Zhang, Guoying – sequence: 5 givenname: Shiyong surname: Liu fullname: Liu, Shiyong email: sliu@ustc.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24786176$$D View this record in MEDLINE/PubMed |
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| Snippet | Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming... |
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| SubjectTerms | Alkaline Phosphatase - antagonists & inhibitors Alkaline Phosphatase - chemistry Alkaline Phosphatase - metabolism composite polymers depolymerization drugs encapsulation enzymatic reactions Hydrogen-Ion Concentration hydrophilicity Hydrophobic and Hydrophilic Interactions hydrophobicity Light Lipase - antagonists & inhibitors Lipase - chemistry Lipase - metabolism Molecular Structure oxygen Particle Size Polymerization Polymers - chemistry Polymers - metabolism protons Surface Properties ultraviolet radiation |
| Title | Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions |
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