Ortho- and Para-Selective Ruthenium-Catalyzed C(sp2)–H Oxygenations of Phenol Derivatives

Versatile ruthenium catalysts allowed for efficient direct oxygenations of aryl carbamates under remarkably mild reaction conditions. In addition to chelation-assisted C–H activation, the optimized ruthenium catalyst proved amenable to para-selective hydroxylations of anisoles without Lewis basic di...

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Bibliographic Details
Published inOrganic letters Vol. 15; no. 13; pp. 3484 - 3486
Main Authors Liu, Weiping, Ackermann, Lutz
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.07.2013
Amer Chemical Soc
Subjects
carbamates
carbon-hydrogen bond activation
catalysts
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
phenol
Physical Sciences
ruthenium
Science & Technology
H BOND ACTIVATION
HYDROXYLATED ARENES
FUNCTIONALIZATION
CLEAVAGES
PALLADIUM
CONSTRUCTION
ALKOXYLATION
DIRECT ARYLATIONS
CONTAINING HETEROCYCLES
C-H
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Summary:Versatile ruthenium catalysts allowed for efficient direct oxygenations of aryl carbamates under remarkably mild reaction conditions. In addition to chelation-assisted C–H activation, the optimized ruthenium catalyst proved amenable to para-selective hydroxylations of anisoles without Lewis basic directing groups.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/ol401535k