Aggregation Control of Robust Water-Soluble Zinc(II) Phthalocyanine-Based Photosensitizers

A water-soluble zinc phthalocyanine (ZnPc) complex with four negatively charged electron-withdrawing sulfonic acid substituents at the nonperipheral positions (α-ZnTSPc) is found to have a high singlet oxygen (1O2) quantum yield and exhibits high photostability. The formation of aggregates is hinder...

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Bibliographic Details
Published inLangmuir Vol. 32; no. 45; pp. 11980 - 11985
Main Authors Ikeuchi, Takuro, Mack, John, Nyokong, Tebello, Kobayashi, Nagao, Kimura, Mutsumi
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.11.2016
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Summary:A water-soluble zinc phthalocyanine (ZnPc) complex with four negatively charged electron-withdrawing sulfonic acid substituents at the nonperipheral positions (α-ZnTSPc) is found to have a high singlet oxygen (1O2) quantum yield and exhibits high photostability. The formation of aggregates is hindered and the highest occupied molecular orbital is significantly stabilized, making α-ZnTSPc potentially suitable for its use as a photosensitizer for photodynamic therapy and photoimmunotherapy. Atomic force microscopy (AFM) reveals that mixtures of the negatively charged α-ZnTSPc complex with a similar positively charged ZnPc were found to result in the self-assembly of one-dimensional accordion-like fibers. Supramolecular fibers can be formed in aqueous solutions through intermolecular electrostatic and donor–acceptor interactions between the two water-soluble ZnPcs.
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ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.6b03552