Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3–5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. A...

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Published inJournal of natural products (Washington, D.C.) Vol. 82; no. 10; pp. 2828 - 2834
Main Authors Tan, Yuen P, Xue, Yongbo, Savchenko, Andrei I, Houston, Sevan D, Modhiran, Naphak, McMillan, Christopher L. D, Boyle, Glen M, Bernhardt, Paul V, Young, Paul R, Watterson, Daniel, Williams, Craig M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 25.10.2019
Amer Chemical Soc
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
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Summary:The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3–5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3–5 was explored, but only limited activity was observed. More extensive antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum antiviral activity against West Nile virus (Kunjin strain, WNVKun) and human influenza viruses H1N1 and H3N2.
Bibliography:Australian Research Council
ObjectType-Article-1
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00522