HKOCl‑2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells

A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macropha...

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Bibliographic Details
Published inOrganic letters Vol. 16; no. 13; pp. 3544 - 3547
Main Authors Hu, Jun Jacob, Wong, Nai-Kei, Gu, Qiangshuai, Bai, Xiaoyu, Ye, Sen, Yang, Dan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 03.07.2014
Amer Chemical Soc
Subjects
Animals
Boron Compounds - chemistry
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
Diagnostic Imaging
fluorescent dyes
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - analysis
Hypochlorous Acid - chemistry
image analysis
macrophages
Macrophages - metabolism
Mice
Molecular Structure
organic compounds
Physical Sciences
Science & Technology
TURN-ON
OXIDATION
MYELOPEROXIDASE
REACTIVE OXYGEN
NEUTROPHIL PHAGOSOME
DYES
MITOCHONDRIA
ATHEROSCLEROSIS
SELECTIVE DETECTION
OXIDANTS
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Summary:A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/ol501496n