Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids

In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together...

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Published inJournal of natural products (Washington, D.C.) Vol. 80; no. 5; pp. 1361 - 1369
Main Authors Isaka, Masahiko, Chinthanom, Panida, Sappan, Malipan, Supothina, Sumalee, Vichai, Vanicha, Danwisetkanjana, Kannawat, Boonpratuang, Thitiya, Hyde, Kevin D, Choeyklin, Rattaket
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 26.05.2017
Amer Chemical Soc
Subjects
Antitubercular Agents - chemistry
Antitubercular Agents - isolation & purification
Antitubercular Agents - pharmacology
Chemistry, Medicinal
Fruiting Bodies, Fungal - chemistry
Ganoderma - chemistry
Ganoderma - isolation & purification
Lanosterol - analogs & derivatives
Lanosterol - chemistry
Lanosterol - isolation & purification
Lanosterol - pharmacology
Life Sciences & Biomedicine
Molecular Structure
Mycelium - chemistry
Mycobacterium tuberculosis - chemistry
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
Structure-Activity Relationship
MYCOBACTERIUM-TUBERCULOSIS
CELLS
METABOLITES
FUNGI
LUCIDUM
TRITERPENES
CULTURES
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Summary:In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure–activity relationships of the antitubercular activity are proposed. Most importantly, 3β- and 15α-acetoxy groups were shown to be critical for antimycobacterial activity. The most potent compound was (24E)-3β,15α-diacetoxylanosta-7,9­(11),24-trien-26-oic acid (35).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.6b00973