Synthetic approaches to the guanosine and xanthosine analogs 5-amino-3-.beta.-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-one and 3-.beta.-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazine-5,7-dione and studies of their antitumor potential

• Published in: Journal of medicinal chemistry Vol. 34; no. 7; pp. 1951 - 1959
• Main Authors: Zou, Ruiming, Beylin, Vladimir G, Groziak, Michael P, Wotring, Linda L, Townsend, Leroy B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.07.1991
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - therapeutic use; Carbohydrates. Nucleosides and nucleotides; Chemical Phenomena; Chemistry; Exact sciences and technology; Guanosine - analogs & derivatives; Guanosine - chemical synthesis; Guanosine - therapeutic use; Leukemia L1210 - drug therapy; Mice; Nucleosides, nucleotides and oligonucleotides; Organic chemistry; Preparations and properties; Ribonucleosides - chemical synthesis; Ribonucleosides - therapeutic use; Tumor Cells, Cultured; Antineoplastic agent; Lactam; Bicyclic compound; Nucleoside; Organic carbamate; Biological activity; Oxygen nitrogen heterocycle

5-Amino-3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-o ne has been synthesized via cyclization of the appropriately protected pyrazofurin derivatives and subsequent transformations of the heterocyclic moiety. This guanosine analogue was marginally cytotoxic to L1210 cells in vitro. The xanthos...