Synthetic approaches to the guanosine and xanthosine analogs 5-amino-3-.beta.-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-one and 3-.beta.-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazine-5,7-dione and studies of their antitumor potential
5-Amino-3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-o ne has been synthesized via cyclization of the appropriately protected pyrazofurin derivatives and subsequent transformations of the heterocyclic moiety. This guanosine analogue was marginally cytotoxic to L1210 cells in vitro. The xanthos...
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Published in | Journal of medicinal chemistry Vol. 34; no. 7; pp. 1951 - 1959 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Chemical Society
01.07.1991
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Subjects | |
Online Access | Get full text |
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Summary: | 5-Amino-3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-o ne has been synthesized via cyclization of the appropriately protected pyrazofurin derivatives and subsequent transformations of the heterocyclic moiety. This guanosine analogue was marginally cytotoxic to L1210 cells in vitro. The xanthosine analogue 3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazine-5,7-dione was also synthesized, and was found to be highly cytotoxic. It appeared to act as a prodrug of pyrazofurin. |
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Bibliography: | istex:0B130F2DDE22ACB571C244AEACFC0765E8CC56BC ark:/67375/TPS-67ZDJQWL-W ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm00111a005 |