Cell Membrane Tracker Based on Restriction of Intramolecular Rotation

• Published in: ACS applied materials & interfaces Vol. 6; no. 12; pp. 8971 - 8975
• Main Authors: Zhang, Chunqiu, Jin, Shubin, Yang, Keni, Xue, Xiangdong, Li, Zhipeng, Jiang, Yonggang, Chen, Wei-Qiang, Dai, Luru, Zou, Guozhang, Liang, Xing-Jie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.06.2014
• Subjects: Calcium - chemistry; Cell Membrane - chemistry; cell membranes; cytotoxicity; Ethylenes - chemistry; Fluorescence; hydrophilicity; Liposomes - chemistry; palmitic acid; Palmitic Acid - chemistry; Peptides - chemistry; photostability; tracker; restriction of intramolecular rotation (RIR); tetraphenylethylene (TPE); cell membrane

The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed sign...