Cell Membrane Tracker Based on Restriction of Intramolecular Rotation

The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed sign...

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Published inACS applied materials & interfaces Vol. 6; no. 12; pp. 8971 - 8975
Main Authors Zhang, Chunqiu, Jin, Shubin, Yang, Keni, Xue, Xiangdong, Li, Zhipeng, Jiang, Yonggang, Chen, Wei-Qiang, Dai, Luru, Zou, Guozhang, Liang, Xing-Jie
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.06.2014
Subjects
Calcium - chemistry
Cell Membrane - chemistry
cell membranes
cytotoxicity
Ethylenes - chemistry
Fluorescence
hydrophilicity
Liposomes - chemistry
palmitic acid
Palmitic Acid - chemistry
Peptides - chemistry
photostability
tracker
restriction of intramolecular rotation (RIR)
tetraphenylethylene (TPE)
cell membrane
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Summary:The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/am5025897