Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission

• Published in: Journal of the American Chemical Society Vol. 136; no. 28; pp. 9890 - 9893
• Main Authors: Wang, Xiaorui, Hu, Jinming, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 16.07.2014; Amer Chemical Soc
• Subjects: antigens; Antigens - chemistry; Biosensing Techniques; biosensors; Carcinoembryonic Antigen - chemistry; Chemistry; Chemistry, Multidisciplinary; crosslinking; enzymatic reactions; enzyme-linked immunosorbent assay; fluorescence; Fluorescent Dyes - chemistry; glucose; Glucose - chemistry; Horseradish Peroxidase - chemistry; Humans; hydrogen peroxide; Hydrogen Peroxide - chemistry; Oxidation-Reduction; peroxidase; Physical Sciences; Reactive Oxygen Species - chemistry; Science & Technology; tyrosine; Tyrosine - chemistry; NANOPARTICLES; ORGANIC DOTS; CHEMISTRY; FLUORESCENT-PROBES; HYDROGEN-PEROXIDE; NANOSTRUCTURES; GENERATION; AIE; IN-SITU; LIVING CELLS

The development of a highly selective and fast responsive fluorogenic biosensor for diverse analytes ranging from bioactive small molecules to specific antigens is highly desirable but remains a considerable challenge. We herein propose a new approach by integrating substrate-selective enzymatic rea...