High-Efficiency Upconversion Luminescent Sensing and Bioimaging of Hg(II) by Chromophoric Ruthenium Complex-Assembled Nanophosphors

A chromophoric ruthenium complex-assembled nanophosphor (N719-UCNPs) was achieved as a highly selective water-soluble probe for upconversion luminescence sensing and bioimaging of intracellular mercury ions. The prepared nanophosphors were characterized by X-ray powder diffraction (XRD), transmissio...

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Bibliographic Details
Published inACS nano Vol. 5; no. 10; pp. 8040 - 8048
Main Authors Liu, Qian, Peng, Juanjuan, Sun, Lining, Li, Fuyou
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.10.2011
Subjects
Cell Survival
Color
Detection
Drinking water
Fourier transforms
HeLa Cells
Humans
Infrared spectroscopy
Luminescence
Luminescent Agents - chemistry
Luminescent Measurements - methods
Medical imaging
Mercury - chemistry
Mercury - metabolism
Molecular Imaging - methods
Nanostructure
Nanostructures - chemistry
Organometallic Compounds - chemistry
Ruthenium - chemistry
Upconversion
Water - chemistry
X-rays
ratiometric
Hg2
upconversion luminescence
bioimaging
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Summary:A chromophoric ruthenium complex-assembled nanophosphor (N719-UCNPs) was achieved as a highly selective water-soluble probe for upconversion luminescence sensing and bioimaging of intracellular mercury ions. The prepared nanophosphors were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDXA), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Further application of N719-UCNPs in sensing Hg2+ was confirmed by optical titration experiment and upconversion luminescence live cell imaging. Using the ratiometric upconversion luminescence as a detection signal, the detection limit of Hg2+ for this nanoprobe in water was down to 1.95 ppb, lower than the maximum level (2 ppb) of Hg2+ in drinking water set by the United States EPA. Importantly, the nanoprobe N719-UCNPs has been shown to be capable of monitoring changes in the distribution of Hg2+ in living cells by upconversion luminescence bioimaging.
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ISSN:1936-0851
1936-086X
DOI:10.1021/nn202620u