Indolin-2-ones with High in Vivo Efficacy in a Model for Multiple Sclerosis
The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. A...
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Published in | Journal of medicinal chemistry Vol. 48; no. 17; pp. 5412 - 5414 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
25.08.2005
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. Activity following po administration was obtained with several analogues and via the use of prodrugs. |
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Bibliography: | ark:/67375/TPS-W59LCSZR-1 Dedicated to Lise and Ernst Binderup on the occasion of their retirement in December 2004. istex:B3DC9A2A79AC4348B414E93239005D234F7E23F3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm0504151 |