Indolin-2-ones with High in Vivo Efficacy in a Model for Multiple Sclerosis

The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. A...

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Published inJournal of medicinal chemistry Vol. 48; no. 17; pp. 5412 - 5414
Main Authors Bouérat, Laëtitia, Fensholdt, Jef, Liang, Xifu, Havez, Sophie, Nielsen, Simon F, Hansen, Jens R, Bolvig, Simon, Andersson, Christina
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 25.08.2005
Amer Chemical Soc
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Summary:The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. Activity following po administration was obtained with several analogues and via the use of prodrugs.
Bibliography:ark:/67375/TPS-W59LCSZR-1
Dedicated to Lise and Ernst Binderup on the occasion of their retirement in December 2004.
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm0504151