Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C–O Bonds

Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C–O and C–N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstitut...

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Bibliographic Details
Published inOrganic letters Vol. 22; no. 8; pp. 2950 - 2955
Main Authors Zeng, Xiaoqin, Zhang, Yuxuan, Liu, Zhengli, Geng, Shasha, He, Yun, Feng, Zhang
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.04.2020
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
CROSS-COUPLING REACTIONS
ACTIVATION
HYDROBORATION
DIFLUOROMETHYLATED ARENES
ALKYL
H BORYLATION
2-PYRIDYL ETHERS
CARBON-OXYGEN
NI
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Summary:Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C–O and C–N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstituted arenes through C–H functionalization using 2-pyridyloxy as the directing group.
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SourceType-Scholarly Journals-1
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content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c00679