Cobalt(III)- and Rhodium(III)-Catalyzed C–H Amidation and Synthesis of 4‑Quinolones: C–H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone

Cobalt­(III) and rhodium­(III) catalysts exhibited complementary scope in C–H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be...

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Published inOrganic letters Vol. 19; no. 7; pp. 1812 - 1815
Main Authors Wang, Fen, Jin, Liang, Kong, Lingheng, Li, Xingwei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.04.2017
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ROOM-TEMPERATURE
AMINATION
AZIDES
REAGENTS
AMIDO TRANSFER
HETEROCYCLES
NATURAL-PRODUCTS
ARENES
N BOND FORMATION
CARBON-NITROGEN BONDS
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Summary:Cobalt­(III) and rhodium­(III) catalysts exhibited complementary scope in C–H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be further utilized in subsequent hydrolysis–cyclization reactions to afford NH 4-quinolones in telescoping reactions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00583