Regioselective One-Pot Benzoylation of Triol and Tetraol Arrays in Carbohydrates

Protection of 2,3,4-O-unprotected α-galacto- and α-fucopyranosides with BzCN and DMAP/DIPEA as the base afforded directly and regioselectively the 3-O-unprotected derivatives. The rationale for these studies was to take advantage of the eventual cooperativity of the “cyanide effect” and “the alkoxy...

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 13; pp. 3862 - 3865
Main Authors Li, Tong, Li, Tianlu, Cui, Tongxiao, Sun, Yajing, Wang, Fengshan, Cao, Hongzhi, Schmidt, Richard R, Peng, Peng
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.07.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CHEMISTRY
DIOLS
OLIGOSACCHARIDES
PROTECTION
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Summary:Protection of 2,3,4-O-unprotected α-galacto- and α-fucopyranosides with BzCN and DMAP/DIPEA as the base afforded directly and regioselectively the 3-O-unprotected derivatives. The rationale for these studies was to take advantage of the eventual cooperativity of the “cyanide effect” and “the alkoxy group mediated diol effect”. This way, even the totally unprotected α-galactopyranosides could be regioselectively transformed into the corresponding 2,4,6-O-protected derivatives. The great utility of these building blocks was demonstrated in efficient trisaccharide syntheses.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01446