Discovery of Plant Growth Stimulants by C–H Arylation of 2‑Azahypoxanthine

A series of new AHX derivatives were synthesized by Pd-catalyzed C–H arylation. Their rice-growth-promoting activity was evaluated in vivo. Among the synthesized compounds, C8 phenyl-substituted AHX showed remarkable growth-promoting activity on rice. The present study shows the power and significan...

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Published inOrganic letters Vol. 20; no. 18; pp. 5684 - 5687
Main Authors Kitano, Hiroyuki, Choi, Jae-Hoon, Ueda, Ayaka, Ito, Hideto, Hagihara, Shinya, Kan, Toshiyuki, Kawagishi, Hirokazu, Itami, Kenichiro
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.09.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
RING-FORMING FUNGUS
FUNCTIONALIZATION
FAIRY RINGS
IMIDAZOLE-4-CARBOXAMIDE
MOLECULES
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Summary:A series of new AHX derivatives were synthesized by Pd-catalyzed C–H arylation. Their rice-growth-promoting activity was evaluated in vivo. Among the synthesized compounds, C8 phenyl-substituted AHX showed remarkable growth-promoting activity on rice. The present study shows the power and significant opportunity of C–H functionalization chemistry to rapidly transform biologically active natural products into more active compounds.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b02407