Enantioselective Direct Functionalization of Indoles by Pd/Sulfoxide-Phosphine-Catalyzed N‑Allylic Alkylation

A general and efficient Pd/sulfoxide-phosphine complex-catalyzed direct asymmetric N-allylic alkylation of indoles has been developed to allow for the preparation of various N-allylated indoles in generally good yields with excellent enantioselectivities. This catalytic system could also be extended...

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Published inOrganic letters Vol. 17; no. 6; pp. 1381 - 1384
Main Authors Chen, Li-Yan, Yu, Xiao-Ye, Chen, Jia-Rong, Feng, Bin, Zhang, Hong, Qi, Ying-Hua, Xiao, Wen-Jing
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 20.03.2015
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ASYMMETRIC-SYNTHESIS
HETEROCYCLES
LIGANDS
ALLYLATION
CONSTRUCTION
FRIEDEL-CRAFTS ALKYLATION
CHIRAL PHOSPHORIC-ACID
DERIVATIVES
CASCADE REACTION
DEAROMATIZATION
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Summary:A general and efficient Pd/sulfoxide-phosphine complex-catalyzed direct asymmetric N-allylic alkylation of indoles has been developed to allow for the preparation of various N-allylated indoles in generally good yields with excellent enantioselectivities. This catalytic system could also be extended to other N-containing heterocycles with good results.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b00077