Rhodium(III)-Catalyzed Synthesis of Naphthols via C–H Activation of Sulfoxonium Ylides

Direct and efficient synthesis of 1-naphthols has been realized via Rh­(III)-catalyzed C–H activation of sulfoxonium ylides and subsequent annulation with alkynes, where the sulfoxonium ylide functioned as a new traceless bifunctional directing group. This reaction occurred under redox-neutral condi...

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Published inOrganic letters Vol. 19; no. 16; pp. 4307 - 4310
Main Authors Xu, Youwei, Yang, Xifa, Zhou, Xukai, Kong, Lingheng, Li, Xingwei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.08.2017
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
KETONES
INHIBITION
ARENES
N BOND
SUBSTITUTED 1-NAPHTHOLS
OXIDATIVE ANNULATION
ALKYNES
ACCESS
CONSTITUENTS
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Summary:Direct and efficient synthesis of 1-naphthols has been realized via Rh­(III)-catalyzed C–H activation of sulfoxonium ylides and subsequent annulation with alkynes, where the sulfoxonium ylide functioned as a new traceless bifunctional directing group. This reaction occurred under redox-neutral conditions with a broad substrate scope.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01974