Nickel-Catalyzed Electrochemical Phosphorylation of Aryl Bromides

A nickel-catalyzed electrochemical cross-coupling reaction of aryl bromides with dialkyl phosphites, ethyl phenylphosphinate, and diphenylphosphine oxide has been developed. This reaction utilizes a simple undivided cell with inexpensive carbon electrodes to synthesize aryl phosphonates, aryl phosph...

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Published inOrganic letters Vol. 21; no. 17; pp. 6835 - 6838
Main Authors Bai, Ya, Liu, Nian, Wang, Shutao, Wang, Siyu, Ning, Shulin, Shi, Lingling, Cui, Lili, Zhang, Zhuoqi, Xiang, Jinbao
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.09.2019
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HALIDES
ELECTROSYNTHESIS
DIPHENYLPHOSPHINE
P-ARYLATION
SECONDARY PHOSPHINE OXIDES
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Summary:A nickel-catalyzed electrochemical cross-coupling reaction of aryl bromides with dialkyl phosphites, ethyl phenylphosphinate, and diphenylphosphine oxide has been developed. This reaction utilizes a simple undivided cell with inexpensive carbon electrodes to synthesize aryl phosphonates, aryl phosphinates, and arylphosphine oxides at room temperature. This protocol provides a mild and efficient route for the construction of C–P bond in moderate to high yields with broad substrate scope.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02475