DNA Photo-cross-linking Using Pyranocarbazole and Visible Light

This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ > 400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 10; pp. 2802 - 2805
Main Authors Fujimoto, Kenzo, Sasago, Shinobu, Mihara, Junichi, Nakamura, Shigetaka
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.05.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
POINT MUTATIONS
MESSENGER-RNA
METHYLPHOSPHONATES
3-CYANOVINYLCARBAZOLE NUCLEOSIDE
ANTIGENE
DUPLEX
CYTOSINE
LINKER
OLIGONUCLEOTIDES
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Summary:This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ > 400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00593