One-Pot Synthesis of Quinazolinones via Iridium-Catalyzed Hydrogen Transfers

A one-pot oxidative cyclization of primary alcohols with o-aminobenzamides to quinazolinones was successfully achieved using [Cp*IrCl2]2 (Cp* = pentamethylcyclopentadienyl) as a catalyst under hydrogen transfer conditions.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 76; no. 19; pp. 7730 - 7736
Main Authors Zhou, Jianguang, Fang, Jie
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.10.2011
Amer Chemical Soc
Subjects
Catalysis
Catalysts: preparations and properties
Chemistry
Chemistry Techniques, Synthetic - methods
Chemistry, Organic
Exact sciences and technology
General and physical chemistry
Green Chemistry Technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Hydrogen - chemistry
Iridium - chemistry
Noncondensed benzenic compounds
Organic chemistry
Physical Sciences
Preparations and properties
Quinazolinones - chemical synthesis
Science & Technology
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Water - chemistry
SECONDARY ALCOHOLS
OXIDATION
FACILE SYNTHESIS
CONVERSION
AMINES
ASTERISK-IR COMPLEX
ALKYLATION
ALDEHYDES
One pot reaction
Hydrogen transfer
Catalytic reaction
Nitrogen heterocycle
Quinazoline derivatives
Transition metal
Primary alcohol
Cyclization
Benzenic compound
Benzamide derivatives
Oxidation
Iridium
Platinoid
Catalyst
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Summary:A one-pot oxidative cyclization of primary alcohols with o-aminobenzamides to quinazolinones was successfully achieved using [Cp*IrCl2]2 (Cp* = pentamethylcyclopentadienyl) as a catalyst under hydrogen transfer conditions.
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ISSN:0022-3263
1520-6904
DOI:10.1021/jo201054k