PERIPHERAL BLOOD STEM CELLS FOR AUTOGRAFTING

• Published in: Annual review of medicine Vol. 48; no. 1; pp. 241 - 251
• Main Authors: Shpall, MD, Elizabeth J, Cagnoni, MD, Pablo J, Bearman, MD, Scott I, Ross, MD, PhD, Maureen, Jones, PhD, MD, Roy B
• Format: Journal Article
• Language: English
• Published: Palo Alto, CA 94303-0139 Annual Reviews 01.01.1997; 4139 El Camino Way, P.O. Box 10139; USA
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; autotransplants; Biological and medical sciences; bone marrow; Bone Marrow Purging; Bone marrow, stem cells transplantation. Graft versus host reaction; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - drug effects; Humans; Medical sciences; Neoplasms - blood; Neoplasms - therapy; peripheral blood progenitor cells; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation, Autologous; Human; Autograft; Treatment; Stem cell; Hematopoietic cell; Bone marrow; Hemopathy; Transplantation; Bone marrow aplasia; Technique; Autotransplantation
• ISSN: 0066-4219; 1545-326X
• DOI: 10.1146/annurev.med.48.1.241

High-dose therapy with autologous hematopoietic progenitor cell support is effective treatment for patients with a variety of high-risk malignancies. Accelerating of marrow recovery from near-lethal or lethal toxicity with hematopoietic cell support improves the safety and cost effectiveness of the high-dose regimens. Peripheral blood progenitor cells will soon replace marrow as the major source of hematopoietic support. This chapter reviews the techniques of peripheral blood progenitor cell collection, mobilization, purification (for tumor removal), and ex vivo expansion.