Neuroprotective Xanthone Glycosides from Swertia punicea

• Published in: Journal of natural products (Washington, D.C.) Vol. 73; no. 8; pp. 1422 - 1426
• Main Authors: Du, Xin-Gang, Wang, Wei, Zhang, Shi-Ping, Pu, Xiao-Ping, Zhang, Qing-Ying, Ye, Min, Zhao, Yu-Ying, Wang, Bao-Rong, Khan, Ikhlas A, Guo, De-An
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 27.08.2010; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Biological and medical sciences; Chemistry, Medicinal; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; General pharmacology; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Hydrogen Peroxide - pharmacology; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Neuropharmacology; Neuroprotective agent; Neuroprotective Agents - chemistry; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Rats; Science & Technology; Swertia - chemistry; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Asia; China; JAPONICA MAKINO; GENTIANELLA; GLUCOSIDES; Trimer; Rat; Adrenal glands; Pharmacognosy; Whole plant; Rodentia; Neuroprotective agent; In vitro; Biological activity; Medicinal plant; Vertebrata; Mammalia; Cell line; Neuron; Folk medicine; Dicotyledones; Angiospermae; Gentianaceae; Plant origin; Isolation; Spermatophyta; Glycoside; C-Glycoside; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np100008r

Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1−5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H2O2-induced PC12 cell damage.