A New Cycloamphilectene Metabolite from the Vanuatu Sponge Axinella sp

• Published in: Journal of natural products (Washington, D.C.) Vol. 65; no. 8; pp. 1210 - 1212
• Main Authors: Ciasullo, L, Cutignano, A, Casapullo, A, Puliti, R, Mattia, C. A, Debitus, C, Riccio, R, Gomez-Paloma, L
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.08.2002; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Axinella; Biological and medical sciences; Chemistry, Medicinal; Chromatography, High Pressure Liquid; Crystallography, X-Ray; cycloamphilectenes; diterpenes; Diterpenes - chemistry; Diterpenes - isolation & purification; General pharmacology; Life Sciences & Biomedicine; Marine; Medical sciences; Molecular Conformation; Molecular Structure; natural products; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Porifera - chemistry; Science & Technology; Stereoisomerism; Vanuatu; Vanuatu; Melanesia; Oceania; ISEW, Pacific, Vanuatu; CYMBASTELA-HOOPERI; DITERPENE ISOCYANIDES; ISONITRILES; Pharmacognosy; Relative configuration; Animal origin; Pyrene derivatives; Tetracyclic compound; X ray diffraction; Marine environment; Porifera; Absolute configuration; Carboxamide; Isolation; Invertebrata; Structural analysis; Crystalline structure
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np010666m

A new diterpene, N-formyl-7-amino-11-cycloamphilectene (1), was isolated from the apolar extract of the Vanuatu sponge Axinella sp. The structure and relative stereochemistry were established by spectroscopic and single-crystal X-ray studies.