Dynamic Behavior of Giant Liposomes at Desired Osmotic Pressures

To apply accurate and uniform osmotic pressures to liposomes, they can be formed using the spontaneous transfer method in solutions with different osmolarities. The majority of liposomes unexpectedly opened large holes (several micrometers in diameter) in response to the osmotic pressure regardless...

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Bibliographic Details
Published inLangmuir Vol. 25; no. 19; pp. 11680 - 11685
Main Authors Ohno, Masae, Hamada, Tsutomu, Takiguchi, Kingo, Homma, Michio
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 06.10.2009
Subjects
Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Liposomes - chemistry
Membranes
Osmotic Pressure
Potassium Chloride - chemistry
Solutions
Sucrose - chemistry
Surface physical chemistry
Time Factors
Water - chemistry
Sucrose
Dynamics
Liposome
Micrometer
Solutes
Osmotic pressure
Diameter
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Summary:To apply accurate and uniform osmotic pressures to liposomes, they can be formed using the spontaneous transfer method in solutions with different osmolarities. The majority of liposomes unexpectedly opened large holes (several micrometers in diameter) in response to the osmotic pressure regardless of its strength, that is, the difference between the outside and inside solute (sucrose or KCl) concentrations. However, the lag time for any response, including the opening of a hole, after the formation of the liposome decreased with increasing osmotic pressure.
Bibliography:ObjectType-Article-1
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ISSN:0743-7463
1520-5827
DOI:10.1021/la900777g