Deoxyribonucleoside 2‘- or 3‘-Mixed Disulfides: Prodrugs To Target Ribonucleotide Reductase and/or To Inhibit HIV Reverse Transcription
Herein, we report the design, synthesis, and biological effects of nucleosides bearing a disulfide function on the sugar ring as prodrugs of potentially active mercaptonucleotides that can target ribonucleotide reductase or reverse transcriptase. We show that cytidine derivatives efficiently reduce...
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Published in | Journal of medicinal chemistry Vol. 46; no. 13; pp. 2565 - 2568 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
19.06.2003
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | Herein, we report the design, synthesis, and biological effects of nucleosides bearing a disulfide function on the sugar ring as prodrugs of potentially active mercaptonucleotides that can target ribonucleotide reductase or reverse transcriptase. We show that cytidine derivatives efficiently reduce dNTP pools in human CEM/SS cells and that 3‘-deoxythymidin-3‘-yl methyl disulfide is able to interfere with both cellular dNTP synthesis and HIV reverse transcription. |
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Bibliography: | istex:85CE68FFA0E8F83CB2B55E6BD98869DD31A5A885 ark:/67375/TPS-9CZMWLJF-N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm0256225 |