Rossinones A and B, Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species

• Published in: Journal of organic chemistry Vol. 74; no. 23; pp. 9195 - 9198
• Main Authors: Appleton, David R, Chuen, Cheah Shiau, Berridge, Michael V, Webb, Victoria L, Copp, Brent R
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 04.12.2009; Amer Chemical Soc
• Subjects: Alicyclic compounds, terpenoids, prostaglandins, steroids; Animals; Antarctic Regions; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Biological and medical sciences; Chemistry; Chemistry, Organic; Exact sciences and technology; Medical sciences; Molecular Structure; Organic chemistry; Pharmacology. Drug treatments; Physical Sciences; Preparations and properties; Science & Technology; Terpenes - chemistry; Terpenes - isolation & purification; Terpenes - pharmacology; Terpenoids; Urochordata - chemistry; Antarctic Regions; RESPIRATORY BURST; METABOLITES; INHIBITORS; MARINE; DERIVATIVES; Antineoplastic agent; Terpenoid; Antiinflammatory agent; Animal origin; Prochordata; Oxygen heterocycle; Biological activity; Urochordata; Characterization; Marine environment; Absolute configuration; Antiviral; Benzenic compound; Isolation; Invertebrata; Spectrophotometry
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo901846j

Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossinones exhibit anti-inflammatory, antiviral and antiproliferative activities.