Isolation, Structure Elucidation, and Chemical Derivatization of a New Cyclic Bisbibenzyl Dimer, Pusilatin E, from the Liverwort Riccardia multifida subsp. decrescens

• Published in: Journal of natural products (Washington, D.C.) Vol. 60; no. 2; pp. 145 - 147
• Main Authors: Yoshida, Tatsuhiko, Toyota, Masao, Asakawa, Yoshinori
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.02.1997; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Biological and medical sciences; BRYOPHYTA; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemistry, Medicinal; COMPOSE PHENOLIQUE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; COMPUESTOS FENOLICOS; DERIVATIVES; EGONOL 2-METHYLBUTANOATE; ESPECTROMETRIA; ESTRUCTURA QUIMICA; General pharmacology; JAPAN; JAPON; Life Sciences & Biomedicine; MARCHANTIN I; Medical sciences; NORNEOLIGNANS; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; PHENOLIC COMPOUNDS; Plant Sciences; PURIFICACION; PURIFICATION; RICCARDIN A; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; STRUCTURE CHIMIQUE; Asia; Japan; BIS(BIBENZYLS); Pharmacognosy; Bryophyta; Oxygen heterocycle; Hepaticae; Macrocycle; Medicinal plant; Chemical modification; Biphenyl derivatives; Plant origin; Phenols; Isolation; Cyclophane; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9605697

A new cyclic bisbibenzyl dimer (1) has been isolated from the MeOH extract of the liverwort Riccardia multifida subsp. decrescens, together with two previously known bisbibenzyls [riccardin A (2) and marchantin I (3)] and a norneolignan [egonol 2-methylbutanoate (4)]. Extensive 1H- and 13C-NMR spectral measurements and chemical derivatization allowed the structure of dimeric riccardin A to be defined; it has been named pusilatin E (1).