Vacancy Engineered Ceria Nanostructures for Protection from Radiation-Induced Cellular Damage

• Published in: Nano letters Vol. 5; no. 12; pp. 2573 - 2577
• Main Authors: Tarnuzzer, Roy W, Colon, Jimmie, Patil, Swanand, Seal, Sudipta
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.12.2005
• Subjects: Apoptosis - drug effects; Apoptosis - radiation effects; Biological and medical sciences; Biomedical Engineering - methods; Breast - cytology; Breast - drug effects; Breast - radiation effects; Breast Neoplasms - pathology; Cerium - administration & dosage; Cerium - chemistry; Chemistry, Pharmaceutical - methods; Cross-disciplinary physics: materials science; rheology; Dosage Forms; Dose-Response Relationship, Radiation; Exact sciences and technology; Humans; Materials science; Medical sciences; Nanopowders; Nanoscale materials and structures: fabrication and characterization; Nanostructures - chemistry; Nanostructures - ultrastructure; Particle Size; Physics; Radiation Dosage; Radiation Protection - methods; Radiation therapy equipment; Radiation Tolerance - drug effects; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Technology. Biomaterials. Equipments. Material. Instrumentation; Tumor Cells, Cultured; Inorganic compounds; Vacancies; Tumor cells; Physical radiation effects; Binary compounds; Cytotoxicity; XRD; Nanostructures; Rare earth compounds; Experimental study; Radiotherapy; Nanoparticles; Damage; Cerium oxides; Nanostructured materials; Radiation protection; X-ray photoelectron spectra
• ISSN: 1530-6984; 1530-6992
• DOI: 10.1021/nl052024f

The ability of engineered cerium oxide nanoparticles to confer radioprotection was examined. Human normal and tumor cells were treated with nanoceria and irradiated, and cell survival was measured. Treatment of normal cells conferred almost 99% protection from radiation-induced cell death, whereas the same concentration showed almost no protection of tumor cells. For the first time, nanoceria is shown to confer radioprotection to a normal human breast line but not to a human breast tumor line, MCF-7.