Well-Defined Lactose-Containing Polymer Grafted onto Silica Particles

• Published in: Biomacromolecules Vol. 7; no. 4; pp. 1196 - 1202
• Main Authors: Guo, Tian-Ying, Liu, Ping, Zhu, Jing-Wei, Song, Mou-Dao, Zhang, Bang-Hua
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.04.2006
• Subjects: Applied sciences; Benzoates - chemistry; Carbohydrate Conformation; Exact sciences and technology; Lactose - analogs & derivatives; Lactose - chemistry; Methacrylates - chemistry; Organic polymers; Particle Size; Physicochemistry of polymers; Polymerization; Polymers - chemical synthesis; Polymers - chemistry; Preparation, kinetics, thermodynamics, mechanism and catalysts; Silanes - chemistry; Silicon Dioxide - chemistry; Methacrylate polymer; Surface reaction; Aldose; Living polymer; Dithioester; Experimental study; Lateral group; Chemical coupling; Free radical polymerization; Chain transfer; Preparation; Microparticle; Silica gel; Glycoside; Graft polymers
• ISSN: 1525-7797; 1526-4602
• DOI: 10.1021/bm051011t

Reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-O-meth-acryloyloxyethoxyl-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)-(1-4)-2,3,6-tri-O-acetyl-β-d-glucopyranoside (MAEL) was performed directly in CHCl3 solutions using cumyl dithiobenzoate (CDB) as the chain transfer agent to give well-defined glycopolymers. The chemical composition and structure of the glycopolymer were characterized by 1HNMR, FTIR, and SEC. The living glycopolymer chains were subsequently grafted onto γ-methacryloxypropyl-trimethoxy (MPTMS) modified silica particles. The acetyl groups of the poly(MAEL) grafted onto the silica gel particles were converted to the hydroxyl groups with CH3ONa/CH3OH, thus obtaining silica gel particles modified with well-defined lactose-carrying polymer.