Arugosin F:  A New Antifungal Metabolite from the Coprophilous Fungus Ascodesmis sphaerospora

• Published in: Journal of natural products (Washington, D.C.) Vol. 61; no. 12; pp. 1566 - 1567
• Main Authors: Hein, Sara M., Gloer, James B., Koster, Brenda, Malloch, David
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.12.1998; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Applied microbiology; arugosin F; Ascodesmis sphaerospora; Ascomycota - chemistry; Benzoxepins - isolation & purification; Benzoxepins - pharmacology; Biological and medical sciences; Chemistry, Medicinal; coprophilous fungi; Fundamental and applied biological sciences. Psychology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbiology; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; Coprophilous; Metabolite; Hemiacetal; Tricyclic compound; Oxygen heterocycle; Ketone; Biological activity; Fungi; Antifungal agent; Phenols; Isolation; Aromatic compound; Antibacterial agent; Thallophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9801918

Chemical studies of the coprophilous fungus Ascodesmis sphaerospora (JS 247) have led to the isolation of arugosin F (1), a new antifungal and antibacterial metabolite. The structure was determined based on NMR and MS data and on comparison with data for known members of the arugosin class. A known xanthone (2) was also isolated.