Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study

Magnetic resonance imaging was used to measure the volumes of the caudate, putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight women) and 26 age- and sex-matched comparison subjects (18 men and eight women). Schizophrenic patients had significantly larger right and left globu...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 151; no. 5; p. 752
Main Authors Elkashef, A M, Buchanan, R W, Gellad, F, Munson, R C, Breier, A
Format Journal Article
LanguageEnglish
Published United States 01.05.1994
Subjects
Adult
Antipsychotic Agents - adverse effects
Basal Ganglia - anatomy & histology
Basal Ganglia - pathology
Caudate Nucleus - anatomy & histology
Caudate Nucleus - pathology
Dyskinesia, Drug-Induced - diagnosis
Dyskinesia, Drug-Induced - etiology
Dyskinesia, Drug-Induced - pathology
Female
Functional Laterality
Globus Pallidus - anatomy & histology
Globus Pallidus - pathology
Humans
Hypertrophy - pathology
Magnetic Resonance Imaging
Male
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - pathology
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Summary:Magnetic resonance imaging was used to measure the volumes of the caudate, putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight women) and 26 age- and sex-matched comparison subjects (18 men and eight women). Schizophrenic patients had significantly larger right and left globus pallidus and right putamen volumes than comparison subjects. There were no significant differences between schizophrenic patients with and without persistent tardive dyskinesia in the volume of any of the three structures.
ISSN:0002-953X
DOI:10.1176/ajp.151.5.752