Discovery of Chemical Inhibitors of Human Bromodomains

Bromodomain inhibitors are examined from their discovery to chemical scaffolds to their crystal structures.

Saved in:
Bibliographic Details
Published inChemical reviews Vol. 115; no. 21; pp. 11625 - 11668
Main Authors Zhang, Guangtao, Smith, Steven G, Zhou, Ming-Ming
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.11.2015
Subjects
Acetyltransferases - antagonists & inhibitors
Acetyltransferases - metabolism
Azepines - chemistry
Azepines - metabolism
Azo Compounds - chemistry
Azo Compounds - metabolism
Carbazoles - chemistry
Carbazoles - metabolism
Chemistry
Crystal structure
Diamines - chemistry
Diamines - metabolism
Drug Evaluation, Preclinical
Human
Humans
Inhibitors
Protein Binding
Protein Structure, Tertiary
Proteins
Quinolines - chemistry
Quinolines - metabolism
Scaffolds
Small Molecule Libraries - chemistry
Small Molecule Libraries - metabolism
Transcription Factors - antagonists & inhibitors
Transcription Factors - metabolism
Online AccessGet full text

Cover

More Information
Summary:Bromodomain inhibitors are examined from their discovery to chemical scaffolds to their crystal structures.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ObjectType-Feature-2
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.5b00205