Antibodies as Carrier Molecules: Encapsulating Anti-Inflammatory Drugs inside Herceptine

The human epidermal growth factor receptor 2 (HER2) is overexpressed in about a third of breast cancer patients, with a strong involvement of the cyclooxygenase-2 (COX-2) enzyme in the tumor progress. HER2 and COX-2 are consequently potential targets for inhibiting carcionogenesis. Herceptin (trastu...

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Bibliographic Details
Published inThe journal of physical chemistry. B Vol. 122; no. 7; pp. 2064 - 2072
Main Authors Cerón-Carrasco, José Pedro, Pérez-Sánchez, Horacio, Zúñiga, José, Requena, Alberto
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 22.02.2018
Subjects
antibodies
antineoplastic activity
drug therapy
encapsulation
erbB-2 receptor
molecular dynamics
neoplasms
nonsteroidal anti-inflammatory agents
patients
prostaglandin synthase
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ISSN1520-6106
1520-5207
1520-5207
DOI10.1021/acs.jpcb.7b10749

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