Antibodies as Carrier Molecules: Encapsulating Anti-Inflammatory Drugs inside Herceptine

• Published in: The journal of physical chemistry. B Vol. 122; no. 7; pp. 2064 - 2072
• Main Authors: Cerón-Carrasco, José Pedro, Pérez-Sánchez, Horacio, Zúñiga, José, Requena, Alberto
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.02.2018
• Subjects: antibodies; antineoplastic activity; drug therapy; encapsulation; erbB-2 receptor; molecular dynamics; neoplasms; nonsteroidal anti-inflammatory agents; patients; prostaglandin synthase
• ISSN: 1520-6106; 1520-5207; 1520-5207
• DOI: 10.1021/acs.jpcb.7b10749

The human epidermal growth factor receptor 2 (HER2) is overexpressed in about a third of breast cancer patients, with a strong involvement of the cyclooxygenase-2 (COX-2) enzyme in the tumor progress. HER2 and COX-2 are consequently potential targets for inhibiting carcionogenesis. Herceptin (trastuzumab) is an antibody that partially blocks HER2-positive cancers at their initial stage. Unfortunately, the overall response rate to the single treatment with this antibody is still modest, and therefore, it needs to be improved by combining several chemotherapeutic agents. On the other hand, nonsteroidal anti-inflammatory drugs (NSAIDs) are designed to halt COX-2 functionality, so they might also exhort an anticancer activity. In this contribution, dual Herceptin–NSAID drugs are designed using theoretical tools. More specifically, blind docking, molecular dynamics, and quantum calculations are performed to assess the stability of 14 NSAIDs embedded inside Herceptin. Our calculations reveal the feasibility of improving the antitumor activity of the parent Herceptin by designing a dual HER2-targeting with Etofenamate. That coupling mode might be used to further rationalize new clinical strategies beyond classical antibody dosages.