Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F] Fluoride

A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical 18F late-stage fluorination of complex small molecules with potential for PET imaging.

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 134; no. 42; pp. 17456 - 17458
Main Authors Lee, Eunsung, Hooker, Jacob M, Ritter, Tobias
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 24.10.2012
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
Fluorine - chemistry
Fluorine Radioisotopes
Molecular Structure
Nickel - chemistry
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Oxidation-Reduction
Physical Sciences
Positron-Emission Tomography
Science & Technology
Water - chemistry
C-H FLUORINATION
REDUCTIVE ELIMINATION
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Summary:A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical 18F late-stage fluorination of complex small molecules with potential for PET imaging.
Bibliography:NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3084797