Pharmacokinetics of Flavanone Glycosides after Ingestion of Single Doses of Fresh-Squeezed Orange Juice versus Commercially Processed Orange Juice in Healthy Humans

• Published in: Journal of agricultural and food chemistry Vol. 62; no. 52; pp. 12576 - 12584
• Main Authors: Silveira, Jacqueline Q, Cesar, Thais B, Manthey, John A, Baldwin, Elizabeth A, Bai, Jinhe, Raithore, Smita
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 31.12.2014; American Chemical Society, Books and Journals Division
• Subjects: absorption; Adult; Beverages - analysis; Beverages - economics; body weight; Citrus sinensis - metabolism; Eating; Female; Flavanones - blood; Flavanones - metabolism; Flavanones - pharmacokinetics; Flavanones - urine; Food Handling; Glycosides - blood; Glycosides - metabolism; Glycosides - pharmacokinetics; Glycosides - urine; hesperidin; Humans; ingestion; Male; metabolites; orange juice; pharmacokinetics; Plant Preparations - blood; Plant Preparations - metabolism; Plant Preparations - pharmacokinetics; Plant Preparations - urine; Young Adult; pharmacokinetics; juice cloud; bioavailability; metabolites; narirutin; hesperidin
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf5038163

Orange juice is a rich source of flavonoids considered beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two styles of orange juice, fresh-squeezed (FOJ) and commercially processed (POJ), differing in their amounts of soluble and insoluble forms of these compounds. Healthy human subjects consumed 11.5 mL/kg body weight of FOJ, and after an interval of 30 days, consumed the same quantity of POJ. The results showed that there were no significant differences in the T max of the pharmacokinetic curves for the metabolites of hesperidin and narirutin following the consumption of the two styles of juices, and corrected for differences in doses in the POJ and FOJ, there were also no significant differences in the AUC and C max values and percent absorption of these compounds.