Minor Iridoids from the Roots of Valeriana wallichii

• Published in: Journal of natural products (Washington, D.C.) Vol. 71; no. 7; pp. 1254 - 1257
• Main Authors: Wang, Rui, Xiao, Dan, Bian, Yan-Hong, Zhang, Xiao-Yue, Li, Bang-Jing, Ding, Li-Sheng, Peng, Shu-Lin
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 01.07.2008; Amer Chemical Soc; American Society of Pharmacognosy; American Chemical Society
• Subjects: 1,5-dihydroxy-3,8-epoxyvalechlorine; 8-methylvalepotriate; Biological and medical sciences; chemical structure; Chemistry, Medicinal; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; General pharmacology; iridoids; Iridoids - chemistry; Iridoids - isolation & purification; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; roots; Science & Technology; spectral analysis; stereochemistry; Valerian - chemistry; Valeriana jatamansi; valeriotetrate; China; Asia; ACTIVE AGENTS; JATAMANSI; Iridoid; Terpenoid; Root; Pharmacognosy; Valerianaceae; Medicinal plant; Folk medicine; Dicotyledones; Acylal; Angiospermae; Plant origin; Isolation; Monoterpene; Spermatophyta; Structural analysis; Below ground plant part
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np070598p

Four new iridoids, valeriotetrates B and C (1 and 2), 8-methylvalepotriate (3), and 1,5-dihydroxy-3,8-epoxyvalechlorine A (4), together with three known iridoids, were isolated from the roots of Valeriana wallichii. The structures of the new compounds were elucidated by analysis of 1D and 2D NMR and HRESIMS data. Compound 4 is an unusual iridoid bearing a C-10 chloro group and an oxo bridge connecting C-3 and C-8, resulting in a rigid skeleton.