Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity
The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1–6) and five known sesquiterpenes (7–11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1–11 were evaluated against select...
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Published in | Journal of natural products (Washington, D.C.) Vol. 70; no. 12; pp. 1915 - 1918 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society and American Society of Pharmacognosy
01.12.2007
Amer Chemical Soc American Society of Pharmacognosy American Chemical Society |
Subjects | |
Online Access | Get full text |
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Summary: | The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1–6) and five known sesquiterpenes (7–11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1–11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine. |
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Bibliography: | http://dx.doi.org/10.1021/np0703996 istex:7EB44AD828A92C698D06CCB04232A66D5F7058BE ark:/67375/TPS-28XG09S2-F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np0703996 |