Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 12; pp. 1915 - 1918
• Main Authors: Suzuki, Kyoko, Okasaka, Mamoru, Kashiwada, Yoshiki, Takaishi, Yoshihisa, Honda, Gisho, Ito, Michiho, Takeda, Yoshio, Kodzhimatov, Olimjon K, Ashurmetov, Ozodbek, Sekiya, Michiko, Ikeshiro, Yasumasa
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 01.12.2007; Amer Chemical Soc; American Society of Pharmacognosy; American Chemical Society
• Subjects: anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Apiaceae; Biological and medical sciences; chemical structure; Chemistry, Medicinal; Colchicine - analysis; Colchicine - pharmacokinetics; cultured cells; cytotoxicity; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; Drug Screening Assays, Antitumor; Ferula - chemistry; Ferula varia; General pharmacology; Humans; KB Cells; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Life Sciences & Biomedicine; Medical sciences; medicinal plants; medicinal properties; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; roots; Science & Technology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; sesquiterpenoid lactones; spectral analysis; traditional medicine; Uzbekistan; Uzbekistan; P-GLYCOPROTEIN FUNCTION; COUMARINS; INHIBITION; Human; Terpenoid; Root; Pharmacognosy; Oriental medicine; Cytotoxicity; Lactone; In vitro; Biological activity; Medicinal plant; Cell line; Dicotyledones; Sesquiterpenes; Angiospermae; Plant origin; Isolation; Spermatophyta; Umbelliferae; Tumor cell; Structural analysis; Below ground plant part
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0703996

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1–6) and five known sesquiterpenes (7–11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1–11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.