Cytotoxic Lignans from the Stem Bark of Magnolia officinalis

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 10; pp. 1687 - 1689
• Main Authors: Youn, Ui-Joung, Chen, Quan Cheng, Jin, Wen-Yi, Lee, Ik-Soo, Kim, Hong-Jin, Lee, Jong-Pill, Chang, Min-Jung, Min, Byung-Sun, Bae, Ki-Hwan
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.10.2007; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: 4'-methoxymagndialdehyde; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; chemical structure; Chemistry, Medicinal; cultured cells; cytotoxicity; Drug Screening Assays, Antitumor; General pharmacology; HeLa Cells; Humans; Inhibitory Concentration 50; Korea; Life Sciences & Biomedicine; lignans; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Magnolia; Magnolia - chemistry; Magnolia officinalis; Medical sciences; medicinal plants; Molecular Structure; Oriental traditional medicine; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant Sciences; Plant Stems - chemistry; Plants, Medicinal - chemistry; Science & Technology; spectral analysis; stereochemistry; Asia; China; Korea; HONOKIOL; OBOVATA; NEOLIGNANS; Leukemia; Lung; Bark; Cytotoxicity; Uterine cervix; Stem; Medicinal plant; Folk medicine; Dicotyledones; Magnoliaceae; Angiospermae; Lignan; Tumor cell; Human; Pharmacognosy; Aldehyde; In vitro; Hela cell line; Biological activity; Cell line; Biphenyl derivatives; Plant origin; Isolation; Spermatophyta; Structural analysis; Benzaldehyde derivatives
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np070388c

Three new lignans, 4′-methoxymagndialdehyde (1), 4′-methoxymagnaldehyde B (2), and 4′-methoxymagnaldehyde E (3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds (4–11). The structures of compounds 1–3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1–11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 µg/mL, respectively.