Synthesis and Insecticidal Activity of N-Substituted (1,3-Thiazole)alkyl Sulfoximine Derivatives

• Published in: Journal of agricultural and food chemistry Vol. 56; no. 23; pp. 11356 - 11360
• Main Authors: Yu, Haibo, Qin, Zhenfang, Dai, Hong, Zhang, Xin, Qin, Xue, Wang, Tingting, Fang, Jianxin
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 10.12.2008; Amer Chemical Soc
• Subjects: (1,3-thiazole)alkyl sulfoximine derivatives; Agriculture; Agriculture, Multidisciplinary; Animals; Aphids - drug effects; bioisosterism; Biological and medical sciences; chemical structure; Chemistry; Chemistry, Applied; Crop and Animal Protection Chemistry; Food industries; Food Science & Technology; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; heterocyclic nitrogen compounds; insecticidal activity; insecticidal properties; insecticides; Insecticides - chemical synthesis; Insecticides - chemistry; Insecticides - pharmacology; Life Sciences & Biomedicine; Myzus persicae; N-substituted alkyl sulfoximine derivatives; nuclear magnetic resonance spectroscopy; peach aphid; pharmacophore; Physical Sciences; Science & Technology; Structure-Activity Relationship; Sulfoximine derivatives; synthesis; synthesis; bioisosterism; Sulfoximine derivatives; insecticidal activity; pharmacophore; peach aphid; RESISTANCE; Insecticide; Synthesis; Fruit; Pesticides; Peach; Thiazole
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf802802g

The N-substituted alkyl sulfoximine derivatives are a new chemical family of neonicotinoid insecticides. We have designed and synthesized 10 (1,3-thiazole)alkyl sulfoximine derivatives. All compounds were identified by 1H and 13C nuclear magnetic resonance (NMR), IR, and elemental analyses. Preliminary bioassays indicated that some title compounds exhibited good insecticidal activities at 10 mg/L against Myzus persicae. The relationship between structure and biological activity was also discussed.