Insight into the Sialome of the Bed Bug, Cimex lectularius

The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts’ hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100 different polypeptides is commonly found by...

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Published inJournal of proteome research Vol. 9; no. 8; pp. 3820 - 3831
Main Authors Francischetti, Ivo M. B, Calvo, Eric, Andersen, John F, Pham, Van M, Favreau, Amanda J, Barbian, Kent D, Romero, Alvaro, Valenzuela, Jesus G, Ribeiro, José M. C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 06.08.2010
Subjects
Acetylcholinesterase - chemistry
Acetylcholinesterase - isolation & purification
Amino Acid Sequence
Animals
Base Sequence
Bedbugs - genetics
Bedbugs - physiology
Computational Biology
DNA Primers - genetics
Enzymes - genetics
Feeding Behavior - physiology
Female
Gene Library
Insect Proteins - isolation & purification
Male
Models, Molecular
Molecular Sequence Data
Phylogeny
Proteomics - methods
Salivary Proteins and Peptides - isolation & purification
Sequence Alignment
Sequence Analysis, DNA
Tandem Mass Spectrometry
saliva
salivary transcriptome
bedbug
salivary proteome
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Summary:The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts’ hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100 different polypeptides is commonly found by transcriptome or proteome analysis of these organisms. Several insect orders or families evolved independently to hematophagy, creating unique salivary potions in the form of novel pharmacological use of endogenous substances and in the form of unique proteins not matching other known proteins, these probably arriving by fast evolution of salivary proteins as they evade their hosts’ immune response. In this work we present a preliminary description of the sialome (from the Greek Sialo = saliva) of the common bed bug Cimex lectularius, the first such work from a member of the Cimicidae family. This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/transcriptome/C_lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/transcriptome/C_lectularius/S2/Cimex-S2.xls
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ISSN:1535-3893
1535-3907
DOI:10.1021/pr1000169