Jusbetonin, the First Indolo[3,2-b]quinoline Alkaloid Glycoside, from Justicia betonica

• Published in: Journal of natural products (Washington, D.C.) Vol. 67; no. 3; pp. 461 - 462
• Main Authors: Subbaraju, Gottumukkala V, Kavitha, Jakka, Rajasekhar, Dodda, Jimenez, Jorge I
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.2004; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Acanthaceae - chemistry; Biological and medical sciences; Chemistry, Medicinal; General pharmacology; India; Indole Alkaloids - chemistry; Indole Alkaloids - isolation & purification; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plant Sciences; Quinolines - chemistry; Quinolines - isolation & purification; Quinolones - chemistry; Quinolones - isolation & purification; Science & Technology; Asia; India; CRYPTOLEPIS-SANGUINOLENTA; IN-VITRO; TOPOISOMERASE-II; NMR-SPECTRA; ANALOGS; GHIESBREGHTIANA; MEDICINAL-PLANTS; VASICINONE; CONSTITUENTS; QUINDOLINE; Nitrogen heterocycle; Pharmacognosy; Glucoside; Plant leaf; Tetracyclic compound; Medicinal plant; Alkaloid; Acanthaceae; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Aromatic compound; Glycoside; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np030392y

A new indolo[3,2-b]quinoline alkaloid glycoside, jusbetonin (1), and three known alkaloids, namely, 10H-quindoline (2), 6H-quinindoline (3), and 5H,6H-quinindolin-11-one (4), have been isolated from the leaves of Justicia betonica. The structure of 1 was established on the basis of 1D and 2D NMR (1H−H COSY, HMQC, and HMBC) and HRFABMS data. Compound 1 is the first example of a glycosylated indolo[3,2-b]quinoline alkaloid, while compound 4 was isolated for the first time from a natural source.