Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Cross-Linked by Schiff’s Base Formation

• Published in: Biomacromolecules Vol. 19; no. 2; pp. 288 - 297
• Main Authors: Hozumi, Takuro, Kageyama, Tatsuto, Ohta, Seiichi, Fukuda, Junji, Ito, Taichi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.02.2018
• Subjects: adipic acid; aldehydes; angiogenesis; Animals; Cross-Linking Reagents - chemistry; crosslinking; gelatin; Gelatin - chemistry; Human Umbilical Vein Endothelial Cells - drug effects; Humans; hyaluronic acid; Hyaluronic Acid - analogs & derivatives; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogels - pharmacokinetics; Hydrogels - pharmacology; Male; Neovascularization, Physiologic - drug effects; oxidation; porosity; Rats; Rats, Sprague-Dawley; Schiff Bases - chemistry; storage modulus; Swine; Tissue Scaffolds - chemistry

We developed an injectable gelatin/hyaluronic acid hydrogel with slow degradability, which consisted of carbohydrazide-modified gelatin (Gel-CDH) and hyaluronic acid monoaldehyde (HA-mCHO). Gel-CDH/HA-mCHO hydrogels were degraded much more slowly in phosphate-buffered saline than the other Schiff’s...