Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid gener...

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Published inACS nano Vol. 10; no. 4; pp. 4199 - 4208
Main Authors Choi, Hyung Woo, Kim, Jihoon, Kim, Jinhwan, Kim, Yonghwi, Song, Hyun Beom, Kim, Jeong Hun, Kim, Kimoon, Kim, Won Jong
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 26.04.2016
Subjects
gatekeeper
pH-jump reagent
corneal wound healing
nitric oxide delivery
calcium phosphate
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Summary:We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.
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ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.5b07483