A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug d...

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Bibliographic Details
Published inACS nano Vol. 13; no. 4; pp. 4354 - 4360
Main Authors Yang, Guang, Chen, Qian, Wen, Di, Chen, Zhaowei, Wang, Jinqiang, Chen, Guojun, Wang, Zejun, Zhang, Xudong, Zhang, Yuqi, Hu, Quanyin, Zhang, Liang, Gu, Zhen
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 23.04.2019
Subjects
microneedle
keratin
drug delivery
hair regrowth
exosome
transdermal drug delivery
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Summary:Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.
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ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/acsnano.8b09573